CHOLESTEROL (a lipid, comes from diet {meat, poultry, fish, dairy} and liver production) is part of the cell membranes, but also is a starting point for steroid/sex hormones (including cortisol, cortisone, and aldosterone in the adrenal glands, and of the sex hormones progesterone, estrogen, and testosterone), also cholesterol is broken down into bile salts which are involved in fat absorption in the digestive system. The insolubility of cholesterol in water is also a factor in the development of arteriosclerosis, the pathological deposition of plaques of cholesterol and other lipids on the insides of major blood vessels, a condition associated with coronary artery disease. This buildup of cholesterol in the blood vessels may constrict the passages considerably and inhibit the flow of blood to and from the heart. In order to travel throught the body cholesterol becomes attached to a lipoprotein. High-density lipoprotein (HDL) carries cholesterol out of the bloodstream for excretion, while low-density lipoprotein (LDL) carries it back into the system for use by various body cells. Researchers believe that HDL and LDL levels in the bloodstream may be at least as important as cholesterol levels, and now measure both to determine risk for heart disease. Reducing consumption of foods containing cholesterol and saturated fat has been found to lower blood cholesterol levels. Cholesterol levels can also be reduced with drugs, most especially with HMG-CoA reductase inhibitors (commonly called “statins”), such as lovastatin (Mevacor) and atorvastatin (Lipitor), and by regular exercise.
CORTICOSTEROID: Any of several steroid hormones secreted by the cortex of the adrenal glands; also synthetic forms with similar properties. Corticosteroids have anti-inflammatory and immunosuppressive effects and may be used to treat a number of conditions, including rheumatoid arthritis, severe allergies, asthma, some skin diseases, and some cancers. Side effects can be serious, and therapy must be withdrawn very gradually.
The two main groups of corticosteroids include
1.glucocorticoids (cortisone, hydrocortisone, prednisone, and dexamethasone), which are essential to carbohydrate, fat, and protein metabolism, and to the body’s response to stress; and
2.mineralocorticoids (aldosterone, fluorocortisone), which control the balance of water and salt in the body.


